Pain is an increasingly common symptom in children and adolescents. Once recurrent pain leads to pain-related disability that affects a child s functional, emotional and social well-being, it is considered a chronic pain disorder. Such disorders can develop as the primary condition or be due to a well-defined underlying physical condition, such as migraine or juvenile idiopathic arthritis. Approximately 5% of the paediatric population suffers from a severe chronic pain disorder. Its treatment in childhood and adolescence is complex and needs to address a variety of biological, psychological and social influencing factors.This treatment manual describes the inpatient treatment programme of one of the world s largest inpatient treatment facilities for chronic pain management in children and adolescents   the German Paediatric Pain Centre. The guidance provided is also applicable to outpatient pain management or day-hospital approaches.