This eye-opening study adds to the scarce scholarly literature on professional athletes, bringing empirical rigor to issues often clouded by mystery and hearsay. It identifies socioeconomic, demographic, and career variables as risk factors for mortality among former NBA and NFL players, along with hypotheses to be tested relating to elite athletes and other U.S. populations. A detailed multivariate analysis compares mortality factors, rates, and outcomes within and between the two leagues, comparing them also with the general U.S. male population. The findings and conclusions gleaned from this research offer possibilities for future research to improve health and quality of life in this specific athlete cohort, among athletes in general, in other groups, and in the larger society.  Potential risk factors analyzed in this groundbreaking study:              Race            Body Mass Index (BMI)            U.S.