Using high-quality, real-world case studies and examples, this introduction to mathematical statistics shows how to use statistical methods and when to use them. This book can be used as a brief introduction to design of experiments. This successful, calculus-based book of probability and statistics, was one of the first to make real-world applications an integral part of motivating discussion. The number of problem sets has increased in all sections. Some sections include almost 50% new problems, while the most popular case studies remain. For anyone needing to develop proficiency with Mathematical Statistics.