This practical, unique textbook provides a foundation for the essential elements of patient safety and quality improvement (QI) for orthopaedic trainees, though the content covered will be of interest to veteran clinicians as well. Currently, there are few existing resources and didactics focused on this crucial yet often overlooked area of medical practice, which makes this the first true textbook on the subject within the field of orthopaedic surgery. Utilizing a user-friendly approach including generous figures, tables, and bulleted key points, the text presents comprehensive background information on QI principles, models, and patient safety. More specifically, it focuses on orthopaedic concerns, such as biologics and implants, registries, checklists, surgical site infection risk reduction, use of evidence-based medicine and care maps, simulation to improve care, and shifting from volume to value, among others.