Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA s high impact studies was created, developed, implemented, analysed and communicated.  In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics. Comprised of 5 sections, the book details the following: <ol>  HIV epidemic in      South Africa and the establishment of a research centre to undertake      clinical, epidemiological and laboratory research on HIV.  CAPRISA s clinical trials on HIV and HSV-2 prevention.