In keeping with the growing emphasis on psychiatry in the medical school curriculum, problem-based learning (PBL) offers students a unique patient-centred, multidisciplinary approach to study and the synthesis of knowledge.The new 2nd edition of Problem-Based Behavioral Science and Psychiatry integrates DSM-5 updates and diagnostic criteria, and is fully consistent with PBL models and methods. Building on the strengths of the popular and widely downloaded 1st edition, the 2nd edition is a clinically robust resource for both the medical and the behavioral science student. Over 40 contributors, many themselves graduates of PBL medical schools, apply problem-based learning methods to specific psychiatric disorders, general clinical issues, and bedrock physician skills such as the intake interview and treatment planning.