This issue of Emergency Medicine Clinics, edited by Dr. Stephen Liang and Rachel Chin, focuses on Infectious Disease Emergencies, with topics including: Cardiovascular and Bloodstream Infections; Pneumonia and Respiratory Tract Infections; Urinary Tract Infections; CNS Infections; Skin and Soft Tissue Infections; MSK infections; Sexually Transmitted Infections; HIV Emergencies; Oncology Infectious Disease Emergencies; Transplant Infectious Disease Emergencies; Emerging Infections in the Emergency Department, Trauma/disaster-related infections; Antimicrobial Stewardship in the Emergency Department; and Infection Prevention in the Emergency Department.