This workbook is designed to teach the major fundamental concepts in Epidemiology, Biostatistics, and clinical research design alongside the textbook  Epidemiology and Biostatistics, 2nd Edition . It is written in concise and organized fashion with many examples to illustrate the concepts deriving from a collection of written materials created to teach Epidemiology and Biostatistics to medical students. The major differences from related titles include a  story  based approach toward teaching the material, relative brevity while maintaining focus on key concepts, and taking the perspective of first-time learners (avoiding and/or clearly defining jargon, using clear common-sense language). It features a variety of questions: long, short, and multiple choice questions. The workbook is made to provide students with the tools necessary to form their own informed conclusions from the clinical research literature.