This book explores connections between music, neural activations and brain plasticity, in order to better understand its associated psychological and physiological effects. The final goal is to focus on the positive effects of music to treat neurological disorders, establishing a new co-ordination between different brain areas to improve both mental illness and wellbeing. A secondary goal is to analyse the role of music at a psycho-sociological level, to understand both the transformation of music into a cultural model and the vision of music as an innate instinct.Music is able to create both emotions and volitional processes. The application of new neuroimaging techniques allows us to explore and evaluate with accuracy what happens in our brain during the creative and artistic performance.