Doody Review ServicesReviewer: Thomas H. Jobe, MD (University of Illinois at Chicago College of Medicine)Description: This book, dedicated to the memory of Dr. Gordon J. Mogenson, a noted Canadian neurophysiologist, brings together experts to treat in detail research on neural circuitry of the mammalian brain that translates motivational and drive states into adaptive behavior. Purpose: The volume meets and exceeds the authors' intention to clarify the anatomy, physiology, pharmacology, and pathophysiology of a set of circuits that connect brain nuclei such as the amygdala, the nucleus accumbens septi, and the pedunculopontine motor region to the reticulospinal tract to demonstrate how drive-related stimuli lead to goal-seeking behavior. Audience: This book provides a very detailed and authoritative treatment of the dopaminergic and adrenergic pathways in the brain. The relationship between the pathways and psychiatric conditions such as schizophrenia, anxiety disorders, and addictive disorders is well developed, making this book a must read for psychiatrists, neuropsychologists, and mental health workers concerned about the biology of these disorders. The addition of the chapters relating the circuits to mental disorders will greatly enhance a readership that would otherwise have been limited to researchers in the field of neurophysiology. Features: Although there are no color pictures, the graphs, photographs, diagrams, and circuit illustrations are of good quality and substantially clarify parts of the text. The book has an attractive cover, useful index, and is well referenced. Assessment: This is an important book because it brings together the latest neuroscience research to establish a new pathway by which motivationally relevant stimuli are factored into the behavior of mammals. Traditionally, the major pathways that output the computations of the CNS have been thought to be the pyramidal tract (cortical) and the extrapyramidal tract (subcortical). A third tract, the reticulospinal tract, has been thought to mediate only local spinal reflex activity. This collection of essaysmakes a convincing case for the view that the reticulospinal tract actually integrates the emotional brain (limbic system) with the other two tracts at the level of the spinal cord. This book contains black-and-white illustrations