This volume is being published at a critical time in U.S. history and serves as a comprehensive and much-needed update to what is known about Latinx health. As both the United States and Latinx subgroups experience demographic shifts, it is critical to examine the current epidemiology of Latinx health, as well as the factors influencing the health and well-being of this growing population.Chapters in this book, written by highly respected experts, illuminate the diversity of the Latinx population and provide strategies to mitigate many of the challenges they face, including challenges related to migrating to new destinations. The book is designed to enrich dialogue around the multilevel determinants of Latinx health and concludes with a call to action for increased culturally congruent, theoretically informed and participatory Latinx health research. The book also encourages the mentorship and growth of early career and junior investigators to conduct research on Latinx health issues.