Utilizing clinical case material of children with diabetes insipidus (DI), this concise, practical pocket guide will provide clinicians with the best real-world strategies to properly diagnose and manage the various manifestations of the disorder they may encounter. It presents a detailed cross-section of pediatric patients, with different etiologies of the disease and possible complications, to provide sensible management scenarios to physicians treating patients with DI. The cases presented include diagnostic strategies and radiological findings for familial and nephrogenic DI as well as DI resulting from hypophysitis, germ cell tumors, Rathkes Cleft Cysts, Langerhans Cell Histiocytosis, craniopharyngiomas, genetic causes, and congenital malformations. Each case focuses on a specific learning objective with clinical pearls, and together these cases represent a comprehensive understanding of children with DI from many aspects.