This issue of Perioperative Nursing Clinics, titled Pain, Analgesia and Anesthesia, which was Guest Edited by Valerie Girard-Powell, RN, will include the following topics: Behavioral Approaches to Pain Management; The Diagnostic Workup of Patients with Neuropathic Pain; Interventional Approaches to Pain Management; Myofascial Pain Trigger Points; Nonopioid Analgesics; Topical Analgesics; Documentation and Potential Tools in Long Term Opioid Therapy for Pain; Critical Monitoring Issues for Surgery Performed in a Non-hospital Setting; Anesthesia for Gastrointestinal Endoscopic Procedures; Anesthesiology and Gastroenterology; Interventional Radiology and Anesthesia; and Fee for Service Payments: Affect on Patient Care, Operating Room Procedures and Anesthesia Services.