Despite global advancements in pediatric medicine, technologies which have become standard-of-care in high-resource settings are unavailable in low-and middle-income countries due to cost, availability, or challenges maintaining equipment. This book compiles evidence-based and expert clinical procedural adaptations in an approachable, case-based, step-by-step guide, aimed to provide educational support for healthcare providers practicing in resource-limited settings. This responds to both the high demand for this content and the importance of gathering experts across continents and pediatric disciplines. Each chapter provides both a theoretical framework and practical discussion of high-yield procedural adaptations. Leading international researchers and seasoned clinicians with expertise using these adaptations were selected by the editors as authors. Chapters include an example case with adaptation use and detailed instructions including supplies, indications, risks, and benefits.