Prostate cancer is the most frequent genitourinary malignancy that garners significant medical and media attention. Over the past decade significant new discoveries have been made that have enabled substantial improvements in screening, diagnosis and management of this disease. Importantly, there has been constant evolution of the best way to treat these patients.<div> </div><div>This text will provide a single, comprehensive reference source that incorporates all the latest information regarding prostate cancer. It will serve as an easy reference source for researchers, clinicians, individuals in training, allied health professionals and medical students regarding prostate cancer by focusing on the controversial points of debate. New data regarding PSA screening, prostate cancer biomarkers, diagnostic evaluation techniques, surveillance protocols, and treatment interventions for localized and more advanced disease will be discussed.