This text provides a concise, yet comprehensive overview of telemedicine in the ICU. The first part of the book reviews common issues faced by practitioners and hospital administrators in implementing and managing tele-ICU programs, including the merits of different staffing models, the challenges of building homegrown programs versus contracting for services, and the impact of state laws and payer policies on reimbursement for tele-ICU services. The second part of the book presents the current state of evidence for and against ICU telemedicine, based on clinical trials, before-and-after implementation studies, and observational data. The third part dives deeper into specific use cases for telemedicine in the ICU, including telestroke, pediatric and cardiac intensive care, and early treatment of declining patients with sepsis.