This comprehensive book is divided into 6 parts that cover all topics related to cerebrospinal fluid (CSF ) rhinorrea. It provides in-depth theoretical and practical knowledge, and includes teaching material as well as evidence-based scientific content. The introductory part presents the skull base anatomy, CSF physiology, pathophysiology of skull base defects as well as the role of imaging in this condition. The second and third parts provide details of different diagnostic features and conservative management. The fourth and central part thoroughly illustrates surgical approaches for this clinical condition and follows a similar structure, describing each surgical procedure step-by-step. The fifth part sheds light on the postoperative management and the long-term follow up, while the last part addresses miscellaneous topics, such as quality of life, outcome measures, and medico-legal issues.