Covers the specialized application of CE to areas of clinical chemistry and drug metabolismHighlights the manipulation of physical parameters that affect CE separation, including sample matrix composition and the control of capillary temperature and electroosmotic flowEmphasizes the practical aspects of performing CE analysesProvides extensive reviews covering general applications for the separation of each class of biomolecule (e.g., ions, pharmaceuticals, peptides, proteins, oligonucleotides, and oligosacharridesDiscusses the theoretical background of CEThree chapters devoted to protein analysisIncludes 296 figures, 42 tables, and 1,530 references The Handbook of Capillary Electrophoresis is a valuable collection of in-depth discussions of specific areas of capillary electrophoresis (CE) that are key to the practical use of CE for sample analysis. The handbook is divided into five parts. Part I focuses on various modes of CE that have been developed and applied to analytical/separation problems. Part II covers detection in CE, with one section reviewing all detector systems that have been successfully interfaced with CE and another that focuses on CE-mass spectrometry. Part III explores how CE can be applied to the analysis of a specific class of molecules/analytes or to solving separation problems. CE analysis of organic ions, pharmaceuticals, glycoconjugates, peptides, proteins, and DNA fragments, the components of single cells, and the utility of capillary coatings in CE are all covered in this section. A key element of this handbook is its discussion of the potential role of CE for solving clinical problems and the potential for CE and CE-MS to advance analysis of drug metabolism. The handbook also presents practical and theoretical discussions on various aspects of CE, including sample matrix and its effects on separation, the need for controlling capillary temperature, and the present and future implications of EOF control. In-depth discussions of this nature comprise Parts IV and V. The Handbook of Capillary Electrophoresis will be an outstanding reference for analytical chemists, biochemists, clinical chemists, cell biologists, and pharmaceutical researchers.