Uses a body systems approach that combines anatomy and physiology with clinical information on basic systems of disease and pathological conditions. Two themes dominate throughout: the complementary nature of structure and function and homeostasis and the clear, accurate description of the body when it is working properly and when it is out of balance. The integrating principle of homeostasis is used to show how "normal" structure and function is achieved and maintained. Failures of homeostasis are shown as basic mechanisms of disease.