A solid understanding of the mechanisms and pathophysiology that underlie vascular disease is essential for the clinical evaluation and optimal management options for millions of patients with vascular disease. It is important that students, residents and practicing clinicians have a solid understanding of how basic science is translated into best clinical practice when managing patients with vascular disease. The thirteen chapters in this eBook have been selected from the contents of two Sections (Basic Science, Pathophysiology) in Rutherford’s Vascular Surgery 8th edition. It provides an up-to-date overview of the current scientific knowledge regarding the mechanisms and pathogenesis of vascular disease. Rutherford’s Vascular Surgery is the most acclaimed and authoritative reference work in the field, and it is hoped that this eBook, utilizing the content from the latest 8th edition of this classic reference work, will provide all clinicians involved in the management of vascular disease with a unique and exciting e-format to access the most current information written by internationally recognized experts, on the basic science associated with vascular disease. This eBook will enable students, trainees and practitioners to access the content by scrolling through their computer, tablet or smart phone.