This handbook highlights the relevance of the social sciences in global public health and their significantly crucial role in the explanation of health and illness in different population groups, the improvement of health, and the prevention of illnesses around the world. Knowledge generated via social science theories and research methodologies allows healthcare providers, policy-makers, and politicians to understand and appreciate the lived experience of their people, and to provide sensitive health and social care to them at a time of most need. Social sciences, such as medical sociology, medical anthropology, social psychology, and public health are the disciplines that examine the sociocultural causes and consequences of health and illness. It is evident that biomedicine cannot be the only answer to improving the health of people.