This forward-looking resource shines needed light on and offers realistic solutions for eliminating health disparities affecting one of the most vulnerable populations: children. Its multilevel framework identifies sources of pediatric health inequities in developmental, societal, familial, financial, and service delivery contexts and sets out innovations for breaking down and addressing longstanding concerns. Plentiful opportunities are described for reducing gaps and promoting equity at various service platforms, from locally-based improvements to systemwide tech upgrades, that can be used as models for revamping larger health policy. And the authors  long-term perspective emphasizes screening, wellness care, early intervention, and prevention strategies to support young patients in the transitions between childhood, adolescence, and young adulthood.