Stuart Orkin, MD, David G Nathan Professor of Pediatrics, Harvard Medical School; Chair, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital; Investigator, Howard Hughes Medical Institute, Boston, Massachusetts David Nathan, MD, President Emeritus, Dana-Farber Cancer Institute, Physician-in-Chief Emeritus, Boston Children's Hospital; Stranahan Distinguished Professor of Pediatrics and Professor of Medicine, Harvard Medical School, Boston, Massachusetts David Ginsburg, MD, James V Neel Distinguished University Professor, Departments of Internal Medicine, Pediatrics, and Communicable Diseases, and Human Genetics, Investigator, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan A. Thomas Look, MD, Professor of Pediatrics, Harvard Medical School; Vice Chair for Research, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, Massachusetts David Fisher, MD, PhD, Chief, Department of Dermatology, Director, Cutaneous Biology Research Center, Massachusetts General Hospital; Director, Melanoma Program, Massachusetts General Hospital Cancer Center, Boston, Massachusetts Samuel Lux, MD, Robert A Stranahan Professor of Pediatrics, Harvard Medical School; Chief Emeritus, Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts