This book discusses the latest research in the pathophysiology, diagnosis, and screening of diabetes and its management. It reviews novel technologies for early diagnosis and highlights the molecular mechanisms of microvascular and macrovascular complications of diabetes 2 mellitus. The book covers the applications of nanotechnology in diagnostics, monitoring, and treatment of diabetes mellitus. The chapter also presents the latest developments in differentiating pancreatic cells from PSCs and illustrates the challenges of their therapeutic application in treating diabetes. The book also explores the prospective medicinal plants comprising either plant extract or isolated bioactive phytoconstituents bearing anti-diabetic potential, which has been reported in several in vitro, in vivo, or clinical studies.