By Robert O. Bonow, MD, Goldberg Distinguished Professor of Cardiology, Northwestern University Feinberg Shool of Medicine; Chief, Division of Cardiology, Northwestern Memorial Hospital, Chicago, IL; Douglas L. Mann, MD, FACC, Professor of Medicine and Gordon Cain Chair, Section of Cardiology, Director, Winters Center for Heart Failure Research, Baylor College of Medicine, Houston, TX; Douglas P. Zipes, MD, Distinguished Professor, Professor Emeritus of Medicine, Pharmacology, and Toxicology, Director Emeritus, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN and Peter Libby, MD, Chief, Cardiovascular Medicine, Brigham and Women's Hospital; Mallinckrodt Professor of Medicine, Harvard Medical School; Reynolds Investigator and Co-Director, Donald W. Reynolds Cardiovascular Clinical Research Center, Brigham and Women's Hospital, Boston, MA