In this book the authors share the strategies and procedures they use in their clinical daily practice to assess and treat complex cases of eating disorders. The strategic and pragmatic approach to the management of medical and psychiatric comorbidity coexisting with eating disorders, while relying on enhanced cognitive behavioral therapy (CBT-E) - an evidence-based treatment recommended for all eating disorder categories both in adults and adolescents-, can also be used by clinicians who adhere to different theoretical models.  The book is divided into two main parts. Part I describes the eating disorder psychopathology and its consequences: an essential knowledge essential to understanding whether the patients have true comorbidity or spurious comorbidity. Then it gives an overview of CBT-E and how to implement it at different levels of care and in a multidisciplinary team.