Knee pain is one of the most common reasons for patient visits to orthopedic, physiatrist, primary care and sports medicine offices. Most books that cover this topic review it as a chapter within a larger book on orthopedics as a whole, or they focus on one specific aspect of knee pathology, such as osteoarthritis. This practical text is an evidence-based, user-friendly review of the literature for the breadth of knee pathologies that present to the busy practitioner. Opening with a review of the relevant anatomy, subsequent chapters discuss injuries to ligaments and tendons, the meniscus, and osteoarthritis. Additional chapters cover knee pain in the pediatric patient, sports trauma and fractures, and rheumatologic and infectious disease considerations.