Prostate cancer is the most commonly diagnosed noncutaneous neoplasm in men in the United States and is the second leading cause of cancer mortality. It poses diagnostic challenges in day-to-day practice in misdiagnosis of tumor-like lesions and secondary tumors. This book is a concise, practical guide to prostate pathology and is structured to guide pathologists, both practicing and trainees, in the diagnostic process. Numerous color images and algorithms show, in a practical manner, how to integrate pathologic and immunohistochemical features to reach a correct diagnosis in prostate tumors and tumor-like lesions. The book incorporates recent developments in biomarkers applied to immunohistochemistry, representing the best immunohistochemistry practice applied to current diagnosis of prostate cancer in biopsies and surgical specimens.