Every DSM-5 diagnosis includes an exclusion criterion that the disorder is not better explained by a medical condition.  Meeting this criterion can be difficult for a variety of reasons. The psychiatric signs and symptoms of medical disorders are not commonly emphasized in medical textbooks. Further, illness scripts for medical diagnoses do not often overlap with psychiatric disorders, making it difficult to know what medical conditions should be ruled out. For example, irritability is a common symptom in polycystic ovarian disorder, but PCOS is rarely on the differential for irritability.  Similarly, while hypothyroidism is commonly linked to the illness script of depression, patients with MDD may be just as likely to have diabetes - an infrequently considered diagnosis for depression.   Buzzword  medical conditions that are commonly prioritized in medical student training can negatively influence classic illness scripts.