The book examines an integrated approach for addressing decisions about the location of healthcare facilities. Supported by Geographic Information Systems (GIS) and Multi-Criteria Decision Analysis (MCDA), the approach provides comprehensive information on territory, taking into account the spatial dimensions. Due to the multiple criteria involved, site selection for urban facilities is a crucial topic in planning decision processes, especially for healthcare facilities. Healthcare provision policies generally fail to address the distribution of facilities within cities, entrusting decisions to various stakeholders. Moreover current evaluation tools focus on the intrinsic performances of healthcare structures, disregarding the extrinsic characteristics, namely those related to the location.