Bringing a compound to market quickly and profitably requires efficient and cost-effective processes for preparing large amounts of the target compound and intermediates. The key to rapid and successful process development is avoiding scale-up problems. This practical guide describes how to anticipate and avoid such problems when processes are being scaled up from the research lab or pilot plant, particularly the chemical preparation of small molecules. The author breaks down process optimization into route, reagent, and solvent selection, development of reaction conditions, workup, and chromatography and crystallization.Book News, Inc.®, Portland, OR Sean T. Nugent, Searle Research & Development... A must reference on every process chemist's (both the novice and the experienced practitioner) desk.