This book chronicles the life and accomplishments of Dorothy Hansine Andersen, a pioneering American pathologist and pediatrician who was the first person to define, diagnose, and treat cystic fibrosis. Divided into three parts, the book begins by detailing Anderson s early life, including being orphaned as an adolescent, her college career, and her laborious start in the medical field. Part II then examines Andersen s role in defining the new disease  cystic fibrosis of the pancreas  and her career of active engagement in various clinical pursuits and research, both in pathology and pediatrics. Chapters in this section also discuss the numerous attempts made by others to minimize Andersen s work through gender bias and the Matilda Effect. The book concludes by reviewing the foundations laid for CF, Andersen s legacy, and her terminal illness.