This issue of Nursing Clinics, Guest Edited by Patricia Howard, features subject topics such as: Interventions for Anxiety in the Critically Ill: A Guide for Nurses and Families;  Psychiatric Co-Morbidities Across the Lifespan; Prevention Approaches in Childhood Mental Health Disorders; Adolescent Substance Use Conditions; Traumatic Brain Injury; Screening and Treatment of Depression in Primary Care; Depression and Co-Morbid Conditions of Adults; Substance Use Interface with Domestic Violence; Assessing and Maintaining Mental Health in Elderly; Global Issues in Mental Health: A Lifespan Approach; Review of Research on Resilience in Family Members of Persons with Mental Illness.