New To This Edition: New chapter on methods: state of the art and forward looking which includes scoping new microscopic methods and puts biopsies in context with other new diagnostics Expanded and enhanced chapter on Tumors with inclusion of cytopathology and use of WHO 2010 classification Fresh approach to fatty liver disease by leaders in the field State of the art new chapter on iron overload with novel approach to classification (guided by the involvement of arguably the world leading scientist in this field.